Saint Meletius, Archbishop of Antioch, was at first a bishop of Sebasteia in Armenia (c.357), and afterwards he was summoned by the emperor Constantius to Antioch to help defend against the Arian heresy, and received there the cathedra.
Saint Meletius struggled quite zealously against the Arian error, but through the intrigues of the heretics he was thrice deposed from his see; Constantius had become surrounded by the Arians and had been swayed over to their position. In all this Saint Meletius was distinguished by an extraordinary gentleness, and he constantly led along his flock by the example of his own virtue and kindly disposition, presupposing that upon suchlike a soil sprouts more readily the seeds of the true teaching of the faith.
Saint Meletius was the one who ordained as deacon the future hierarch Saint Basil the Great. And Saint Meletius also baptised and encouraged the growth under him of another of the greatest luminaries of Orthodoxy, Saint John Chrysostom, who afterwards wrote an eulogy to his former archpastor.
After Constantius, the throne was occupied by Julian the Apostate, and the saint again was expelled, having to hide himself away in secret places for his safety. But again returning under the emperor Jovian in the year 363, Saint Meletius wrote his theological tract, “Exposition of the Faith,” which facilitated the conversion to Orthodoxy of many of the Arians.
In the year 381, under the emperor Theodosius the Great (379-395), the Second Ecumenical Council was convened. Already in the year 380 the saint had set off on his way to the Second Ecumenical Council at Constantinople, and came to preside over it. Before the start of the Council, Saint Meletius raised up his hand displaying three fingers, and then conjoining together two fingers and bending the one he blessed the people, proclaiming: “We apprehend three hypostatic-persons, and we speak about one self-same nature,” and with this declaration of the saint there flashed the fire of a lightning-bolt. During the time of the Council Saint Meletius expired to the Lord. Saint Gregory of Nyssa honoured the memory of the deceased with an eulogistic word.
There are preserved discourses of Saint Meletius concerning the One-in-Essence nature of the Son of God with God the Father, and also his letter to the emperor Jovian about the confessing of the Holy Trinity. The relics of Saint Meletius were transferred from Constantinople to Antioch.